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tenacia
Utente Attivo
Regione: Puglia
Prov.: Bari
724 Messaggi |
 Inserito il - 06/03/2010 : 11:17:48
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Sotto controllo per diversi anni centinaia di migliaia di pazienti
SCLEROSI MULTIPLA: COLLEGAMENTO CON EBV
(AGI) - Boston, 5 mar. - L'infezione da Epstein-Barr virus (Ebv) causa la sclerosi multipla. A scoprire per primi una evidenza diretta tra questo tipo di infezione e la malattia degenerativa sono stati un gruppo di ricercatori della Harvard School of pubblic Health e del Walter Reed Army Institute of Research che hanno pubblicato i risultati delle loro ricerche sulla rivista Annals of Neurology. Per verificare il ruolo giocato dall'infezione da Ebv sul rischio sclerosi multipla i ricercatori guidati da Alberto Ascherio hanno tenuto sotto controllo centinaia di migliaia di pazienti non affetti da Ebv per diversi anni. In questo modo hanno potuto osservare il momento in cui avevano contratto l'infezione e valutare il rischio effettivo di sviluppare, come conseguenza la sclerosi multipla. Ebv e' un virus della famiglia degli herpes virus ed e' tra i piu' comuni. L'infezione di solito asintomatica viene contratta da piccoli. Se pero' l'infezione avviene da adulti e' spesso associata ad alcune forme di mononucleosi. Negli Stati Uniti il 95 per cento degli adulti sono positivi all'Ebv ma senza sintomi. Il virus e' anche associato ad alcune forme di cancro e causa problemi seri in alcuni pazienti immunodepressi. Lo studio ha evidenziato un rischio sclerosi molto alto nei soggetti che avevano sia una predisposizione genetica alla malattia che una infezione da Ebv. Al contrario nei soggetti non infetti, pur con storie di familiarita' della sclerosi, il rischio di sviluppare la malattia era molto piu' basso. .
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Un giorno senza sorriso ? un giorno perso.
Charlie Chaplin |
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Roby
Utente Master
Regione: Lombardia
Prov.: Bergamo
Città: Clusone
3022 Messaggi |
Inserito il - 06/03/2010 : 11:29:04
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INTERESSANTE, MA VORREI SAPERE COME GUARIRE |
Roby |
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zero16
Utente Master
Regione: Sicilia
Prov.: Palermo
Città: Palermo
6342 Messaggi |
Inserito il - 06/03/2010 : 13:30:21
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Fa piacere vedere che si stanno svegliando tutti a sottolineare che ci sono anche loro, bravi, guadagnatevi il pane (e i fondi per la ricerca). Ma dov'? pubblicato questo studio? Da un po' preferisco andarmeli a leggere da solo e trarre le conclusioni senza intermediazioni giornalistiche.
Ottima domanda, Roby. Una pillola di antivirale al d |
HO VISTO COSE CHE VOI ASTEMI NON POTETE NEANCHE IMMAGINARE... |
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Giuliana.
Utente Attivo
770 Messaggi |
Inserito il - 06/03/2010 : 15:09:27
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http://www.eurekalert.org/pub_releases/2010-03/hsop-rff030410.php
http://www.hsph.harvard.edu/
Press Releases
2010 Releases
Researchers Find Further Evidence Linking Epstein-Barr Virus and Risk of Multiple Sclerosis
First Long-term Study Among Individuals Not Infected with EBV Suggests EBV Infection Likely to be a Cause of MS, Not a Consequence
For immediate release: Thursday, March 4, 2010
Boston, MA ? Researchers from the Harvard School of Public Health, Walter Reed Army Institute of Research, and a team of collaborators have observed for the first time that the risk of multiple sclerosis (MS) increases by many folds following infection with the Epstein-Barr virus (EBV). This finding implicates EBV as a contributory cause to multiple sclerosis. The study appears in an advance online edition of the journal Annals of Neurology and will appear in a later print edition.
Hundred of thousands of individuals not infected with EBV were followed up for several years through repeated blood samples collections. Researchers were then able to determine the time when individuals developed an EBV infection and its relation to MS onset. ?The recruitment of individuals before they were infected with EBV and following up with them for several years is the critical methodological aspect that makes this study qualitatively different from all previous work,? said Alberto Ascherio, senior author of the study and professor of epidemiology and nutrition at Harvard School of Public Health and professor of medicine at Harvard Medical School.
MS is a chronic degenerative disease of the central nervous system. Women are more likely than men to get the disease and it is the most common neurologically disabling disease in young adults. Although genetic predisposition plays an important role in determining susceptibility, past studies have shown that environmental factors are equally important.
EBV is a herpes virus and one of the most common human viruses worldwide. Infection in early childhood is common and usually asymptomatic. Late age at infection, however, often causes infectious mononucleosis. In the U.S., upwards of 95% of adults are infected with the virus, but free of symptoms. EBV has been associated with some types of cancer and can cause serious complications when the immune system is suppressed, for example, in transplant recipients. There is no effective treatment for EBV.
This is the first study based on the longitudinal follow-up of several thousand individuals who were not infected with EBV at the time of recruitment. The study population was made up of active-duty US Army, Navy, and Marines personnel who have at least one blood sample in the Department of Defense Serum Repository. The electronic databases of the Physical Disability Agencies of the US Army and Navy were then searched for individuals whose records indicated a possible diagnosis of MS reported between 1992 and 2004.
The researchers selected 305 individuals diagnosed with MS and who had blood specimens collected before the date of their diagnosis. Two controls for each case were then selected from the serum database and matched by branch of service, sex, date of blood collection, and age at time of blood collection.
The study found that MS risk is extremely low among individuals not infected with EBV, but it increases sharply in the same individuals following EBV infection.
?The observation that MS occurred only after EBV is a big step forward,? said Alberto Ascherio. ?Until now we knew that virtually all MS patients are infected with EBV, but we could not exclude two non-causal explanations for this finding: that EBV infection is a consequence rather than a cause of MS, and that individuals who are EBV negative could be genetically resistant to MS. Both of these explanations are inconsistent with the present findings,? said Ascherio.
?The evidence is now sufficiently compelling to justify the allocation of more resources to the development of interventions targeting EBV infection, or the immune response to EBV infection, as these may contribute to MS prevention,? he said.
The study was supported by a grant from the National Institute of Neurological Disorders and Stroke.
?Primary Infection with the Epstein-Barr Virus and Risk of Multiple Sclerosis,? Lynn I. Levin, Kassandra L. Munger, Eilis J. O?Reilly, Kerstin I. Falk, Alberto Ascherio, Annals of Neurology, online January 20, 2010
For further information:
Todd Datz
tdatz@hsph.harvard.edu
617.432.3952 617.432.3952
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Harvard School of Public Health ( http://www.hsph.harvard.edu ) is dedicated to advancing the public's health through learning, discovery, and communication. More than 400 faculty members are engaged in teaching and training the 1,000-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence prevention; from maternal and children's health to quality of care measurement; from health care management to international health and human rights. For more information on the school visit: http://www.hsph.harvard.edu
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E riecco l'EBV
